Supernatural Season 6 Episode 10: Caged Heat

Meg kidnaps Sam and Dean and tries to force them to tell her where Crowley is hiding. Sam makes her a deal - they will help her find Crowley if she promises to torture him for information about how to get Sam's soul back. Castiel joins the fight but finds it difficult to work with Meg.

Supernatural Season 5 Episode 10: Abandon All Hope

Dean and Sam get to know the whereabouts of Lucifer and want to hunt him down. But Lucifer is well prepared and is working his own plans.

Supernatural Season 4 Episode 10: Heaven and Hell

Dean and Sam figure out why Castiel and his superior/handler, Uriel the Angel of Death, want Anna Milton dead when the three of them are forced to go on the run, not only from heavenly and vengeful angels, but from Alastair and his demon minions who also try to track down Sam, Dean, and Anna. With the assistance from the now-blind soothsayer, Pamela Barnes, they discover that 'Anna' is a fallen (former) angel and needs to seek her grace wings before the forces of both Heaven and Hell find them.

Supernatural Season 3 Episode 10: Dream a Little Dream of Me

When Bobby Singer is discovered in a coma, Dean and Sam uncover a demon who works through people's dreams to destroy them.

Supernatural Season 2 Episode 10: Hunted

Sam is shocked when Dean finally tells him their dad asked him to watch over Sam to save him, or if that fails kill him. Sam leaves alone to let Ash look up a same-type clairvoyant demonic victim. Ava Wilson, from Peoria, Indiana, fits that bill and looks up Sam to warn she saw his death, then leaves ridiculing him. Dean followed Sam, just in time to intervene when crazy Gordon Walker turns up, who will stop at nothing to destroy 'utterly evil' Sam. It's a testing fight for the brothers.

Supernatural Season 1 Episode 10: Asylum

Sam and Dean investigate an abandoned sanitarium and discover that when the hospital was open, the patients held a revolt against the cruel and unusual experimental treatments carried out by the head doctor. Now the ghosts roam the halls, driving anyone who spends the night insane. While trying to rescue two lost teenagers, Sam is captured and turns against Dean.